Literatur Riview: Flavonoid Activity As an Anti-Cancer Compound

ABSTRACT The activity of flavonoids as anti-cancer compounds has attracted the attention researchers. Flavonoids are natural found in various plants and have been identified potential candidates for drugs. multiple mechanisms action, including inhibiting cancer cell growth, inducing apoptosis, formation new blood vessels. also possess antioxidant properties that protect normal cells from oxidative damage. In vitro vivo studies demonstrated significant such quercetin, kaempferol, genistein, apigenin against types cancer, breast, colorectal, lung, prostate cancer. Moreover, can enhance effectiveness conventional therapies reduce their side effects, making them promising adjuvant treatment. However, further research is needed to gain a deeper understanding action flavonoids, improve bioavailability, conduct clinical trials humans. Exploring sources structural modifications activity. application advanced technologies methods molecular biology, gene therapy help uncover full compounds. Keywords: Flavonoid, Anti-Cancer Activity, Mechanisms Action, Cancer Therapy, Quercetin, Kaempferol, Genistein, Apigenin. ABSTRAK Aktivitas flavonoid sebagai senyawa anti-kanker. Flavonoid merupakan alami yang ditemukan dalam berbagai tumbuhan dan telah menarik perhatian peneliti kandidat potensial untuk obat memiliki mekanisme aksi, termasuk menghambat pertumbuhan sel kanker, menyebabkan pembentukan pembuluh darah baru. juga sifat antioksidan melindungi sel-sel dari kerusakan oksidatif. Penelitian menunjukkan bahwa seperti potensi anti-kanker signifikan pada jenis kanker payudara, kolorektal, paru-paru, prostat. Selain itu, dapat meningkatkan efektivitas terapi konvensional mengurangi efek sampingnya, sehingga menjanjikan tambahan pengobatan kanker. Namun, penelitian lanjutan diperlukan memahami lebih lanjut tentang aksi flavonoid, bioavailabilitas, melakukan uji klinis manusia. Penggalian sumber-sumber baru modifikasi struktural aktivitas mereka. Penerapan teknologi metode terkini biologi molekuler, sel, gen membantu mengungkap penuh Kata Kunci: Anti-Kanker, Mekanisme Aksi, Terapi Kanker, Apigenin